Review





Similar Products

opal multiplex ihc kit 261  (Akoya Biosciences)
96
Akoya Biosciences opal multiplex ihc kit 261
Opal Multiplex Ihc Kit 261, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex ihc kit 261/product/Akoya Biosciences
Average 96 stars, based on 1 article reviews
opal multiplex ihc kit 261 - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
opal multiplex ihc kit  (Akoya Biosciences)
96
Akoya Biosciences opal multiplex ihc kit
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Opal Multiplex Ihc Kit, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex ihc kit/product/Akoya Biosciences
Average 96 stars, based on 1 article reviews
opal multiplex ihc kit - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
opal multiplex 7 color ihc kit  (Akoya Biosciences)
96
Akoya Biosciences opal multiplex 7 color ihc kit
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Opal Multiplex 7 Color Ihc Kit, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex 7 color ihc kit/product/Akoya Biosciences
Average 96 stars, based on 1 article reviews
opal multiplex 7 color ihc kit - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
automation multiplex detection kit  (Akoya Biosciences)
95
Akoya Biosciences automation multiplex detection kit
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Automation Multiplex Detection Kit, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/automation multiplex detection kit/product/Akoya Biosciences
Average 95 stars, based on 1 article reviews
automation multiplex detection kit - by Bioz Stars, 2026-03
95/100 stars
  Buy from Supplier
opal multiplex detection kit  (Akoya Biosciences)
95
Akoya Biosciences opal multiplex detection kit
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Opal Multiplex Detection Kit, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex detection kit/product/Akoya Biosciences
Average 95 stars, based on 1 article reviews
opal multiplex detection kit - by Bioz Stars, 2026-03
95/100 stars
  Buy from Supplier
opal multiplex manual detection kit  (Akoya Biosciences)
96
Akoya Biosciences opal multiplex manual detection kit
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Opal Multiplex Manual Detection Kit, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex manual detection kit/product/Akoya Biosciences
Average 96 stars, based on 1 article reviews
opal multiplex manual detection kit - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
opal multiplex ihc system  (Akoya Biosciences)
96
Akoya Biosciences opal multiplex ihc system
A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex <t>IF-IHC</t> <t>staining</t> ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.
Opal Multiplex Ihc System, supplied by Akoya Biosciences, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/opal multiplex ihc system/product/Akoya Biosciences
Average 96 stars, based on 1 article reviews
opal multiplex ihc system - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier

Image Search Results


A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex IF-IHC staining ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.

Journal: Oncogenesis

Article Title: Rab37-mediated OPN secretion enriches SPP1 + macrophages through autocrine–paracrine signaling to drive lung tumor progression

doi: 10.1038/s41389-026-00596-3

Figure Lengend Snippet: A UMAP visualization of macrophage subclusters, showing three distinct populations defined by gene marker expression. B Distribution of macrophage subclusters across Rab37 WT and KO normal and tumor lung tissues. Multiplex IF-IHC staining ( C ) and quantitative analysis ( D ) of orthotopic lung tumor tissues from Rab37 WT and KO mice, showing CD163 (blue) co-localization with OPN (red). Nuclei were counterstained with DAPI (white). Yellow arrows indicate CD163 + / OPN + cells. Scale bar, 20 μm. E , F Representative images of multiplex IF-IHC staining of lung cancer patient samples showing triple labeling of CD163 (blue), Rab37 (green), and OPN (red) in tumor sections (Scale bar, 20 μm), with enlarged views highlighting co-localization. Yellow arrows indicate CD163 + /Rab37 + /OPN + cells, while white arrows denote CD163 + /OPN + cells ( E ). Quantification of CD163 + Rab37 + OPN + tumor-associated macrophages in patients without recurrence and with recurrence ( F ). Kaplan–Meier survival curves comparing overall ( G ) and recurrence-free ( H ) survival of patients stratified by the percentage of OPN + /Rab37 + /CD163 + cells. I Pathway enrichment analysis based on differentially expressed genes in Spp1 + macrophages. Data are presented as mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, Student’s t test.

Article Snippet: Staining was performed using the Opal Multiplex IHC kit (#NEL810001KT, Akoya Biosciences, Marlborough, MA, USA) according to the manufacturer’s instructions.

Techniques: Marker, Expressing, Multiplex Assay, Immunohistochemistry, Labeling